With one of the most devastating losses in the history of British politics—a 432-to-202 vote in the House of Commons on Tuesday—Prime Minister Theresa May was handed a rebuke of her proposed Brexit framework for the future relationship between the European Union and the United Kingdom.

The vote, which comes as the clock continues ticking toward a March deadline for a voter-decreed EU separation, has triggered yet another no-confidence vote that could force May from office.